SAFER: Search and Find Emergency Rover

When disaster strikes and causes a structure to collapse, it poses a unique challenge to search and rescue teams as they assess the situation and search for survivors. Currently there are very few tools that can be used by these teams to aid them in gathering important information about the situation that allow members to stay at a safe distance. SAFER, Search and Find Emergency Rover, is an unmanned, remotely operated vehicle that can provide early reconnaissance to search and rescue teams so they may have more information to prepare themselves for the dangers that lay inside the wreckage. Over the past year, this team has restored a bare, non-operational chassis inherited from Roverwerx 2012 into a rugged and operational rover with increased functionality and reliability. SAFER uses a 360-degree camera to deliver real time visual reconnaissance to the operator who can remain safely stationed on the outskirts of the disaster. With strong drive motors providing enough torque to traverse steep obstacles and enough power to travel at up to 3 ft/s, SAFER can cover ground quickly and effectively over its 1-3 hour battery life, maximizing reconnaissance for the team. Additionally, SAFER contains 3 flashing beacons that can be dropped by the operator in the event a victim is found so that when team members do enter the scene they may easily locate victims. In the future, other teams may wish to improve upon this iteration by adding thermal imaging, air quality sensors, and potentially a robotic arm with a camera that can see in spaces too small for the entire rover to enter

Transition Pathways to Sustainable Agricultural Water Management: A Review of Integrated Modeling Approaches

Agricultural water management (AWM) is an interdisciplinary concern, cutting across traditional domains such as agronomy, climatology, geology, economics, and sociology. Each of these disciplines has developed numerous process-based and empirical models for AWM. However, models that simulate all major hydrologic, water quality, and crop growth processes in agricultural systems are still lacking. As computers become more powerful, more researchers are choosing to integrate existing models to account for these major processes rather than building new cross-disciplinary models. Model integration carries the hope that, as in a real system, the sum of the model will be greater than the parts. However, models based upon simplified and unrealistic assumptions of physical or empirical processes can generate misleading results which are not useful for informing policy. In this article, we use literature and case studies from the High Plains Aquifer and Southeastern United States regions to elucidate the challenges and opportunities associated with integrated modeling for AWM and recommend conditions in which to use integrated models. Additionally, we examine the potential contributions of integrated modeling to AWM — the actual practice of conserving water while maximizing productivity

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

Background Non-alcoholic steatohepatitis (NASH) is a common type of chronic liver disease that can lead to cirrhosis. Obeticholic acid, a farnesoid X receptor agonist, has been shown to improve the histological features of NASH. Here we report results from a planned interim analysis of an ongoing, phase 3 study of obeticholic acid for NASH. Methods In this multicentre, randomised, double-blind, placebo-controlled study, adult patients with definite NASH,non-alcoholic fatty liver disease (NAFLD) activity score of at least 4, and fibrosis stages F2–F3, or F1 with at least oneaccompanying comorbidity, were randomly assigned using an interactive web response system in a 1:1:1 ratio to receive oral placebo, obeticholic acid 10 mg, or obeticholic acid 25 mg daily. Patients were excluded if cirrhosis, other chronic liver disease, elevated alcohol consumption, or confounding conditions were present. The primary endpointsfor the month-18 interim analysis were fibrosis improvement (≥1 stage) with no worsening of NASH, or NASH resolution with no worsening of fibrosis, with the study considered successful if either primary endpoint was met. Primary analyses were done by intention to treat, in patients with fibrosis stage F2–F3 who received at least one dose of treatment and reached, or would have reached, the month 18 visit by the prespecified interim analysis cutoff date. The study also evaluated other histological and biochemical markers of NASH and fibrosis, and safety. This study is ongoing, and registered with ClinicalTrials.gov, NCT02548351, and EudraCT, 20150-025601-6. Findings Between Dec 9, 2015, and Oct 26, 2018, 1968 patients with stage F1–F3 fibrosis were enrolled and received at least one dose of study treatment; 931 patients with stage F2–F3 fibrosis were included in the primary analysis (311 in the placebo group, 312 in the obeticholic acid 10 mg group, and 308 in the obeticholic acid 25 mg group). The fibrosis improvement endpoint was achieved by 37 (12%) patients in the placebo group, 55 (18%) in the obeticholic acid 10 mg group (p=0·045), and 71 (23%) in the obeticholic acid 25 mg group (p=0·0002). The NASH resolution endpoint was not met (25 [8%] patients in the placebo group, 35 [11%] in the obeticholic acid 10 mg group [p=0·18], and 36 [12%] in the obeticholic acid 25 mg group [p=0·13]). In the safety population (1968 patients with fibrosis stages F1–F3), the most common adverse event was pruritus (123 [19%] in the placebo group, 183 [28%] in the obeticholic acid 10 mg group, and 336 [51%] in the obeticholic acid 25 mg group); incidence was generally mild to moderate in severity. The overall safety profile was similar to that in previous studies, and incidence of serious adverse events was similar across treatment groups (75 [11%] patients in the placebo group, 72 [11%] in the obeticholic acid 10 mg group, and 93 [14%] in the obeticholic acid 25 mg group). Interpretation Obeticholic acid 25 mg significantly improved fibrosis and key components of NASH disease activity among patients with NASH. The results from this planned interim analysis show clinically significant histological improvement that is reasonably likely to predict clinical benefit. This study is ongoing to assess clinical outcomes

Transition Pathways to Sustainable Agricultural Water Management: A Review of Integrated Modeling Approaches

Agricultural water management (AWM) is an interdisciplinary concern, cutting across traditional domains such as agronomy, climatology, geology, economics, and sociology. Each of these disciplines has developed numerous process-based and empirical models for AWM. However, models that simulate all major hydrologic, water quality, and crop growth processes in agricultural systems are still lacking. As computers become more powerful, more researchers are choosing to integrate existing models to account for these major processes rather than building new cross-disciplinary models. Model integration carries the hope that, as in a real system, the sum of the model will be greater than the parts. However, models based upon simplified and unrealistic assumptions of physical or empirical processes can generate misleading results which are not useful for informing policy. In this article, we use literature and case studies from the High Plains Aquifer and Southeastern United States regions to elucidate the challenges and opportunities associated with integrated modeling for AWM and recommend conditions in which to use integrated models. Additionally, we examine the potential contributions of integrated modeling to AWM — the actual practice of conserving water while maximizing productivity

Microsurgical Clipping of Carotid-Ophthalmic Tandem Aneurysms: Case Report and Surgical Nuances.

Tandem intracranial aneurysms (TandIAs) are rare but inherently complex, and special technical considerations are required for their surgical management. The present case highlights the key surgical aspects of two carotid-ophthalmic TandIAs incidentally found in a 60-year-old female. Both the aneurysms were superiorly projecting, regular in size, and involved the left ophthalmic segment of the internal carotid artery (ICA). The minimum distance between the necks was 3 mm. The patient underwent microsurgery because of the reported major complications rate of the endovascular treatment in the case of a very short minimum distance between the TandIAs. After cervical ICA exposure, both the aneurysms were excluded through a pterional approach. Intradural anterior clinoidectomy and unroofing of the optic canal allowed the mobilization of the left optic nerve. The more distal aneurysm was clipped before the opening of the distal dural ring of the ICA. The proximal aneurysm was clipped with two straight clips stacked perpendicular to the ICA. A small remnant was intentionally left to avoid the stenosis of the ophthalmic artery. Postoperative angiography showed the exclusion of both the aneurysms with a small dog-ear of the more proximal one. The patient was discharged neurologically intact and, after one year, the remnant remained stable. Microsurgical clipping is a definitive and durable treatment for carotid-ophthalmic TandIAs. In the case of a very short minimum distance between the aneurysms, the distal one should be clipped first to make the anterior clinoidectomy, opening of the distal dural ring of the ICA, and clipping of the more proximal aneurysm easier

Long‐term research catchments to investigate shrub encroachment in the Sonoran and Chihuahuan deserts: Santa Rita and Jornada experimental ranges

Woody plant encroachment is a global phenomenon whereby shrubs or trees replace grasses. The hydrological consequences of this ecological shift are of broad interest in ecohydrology, yet little is known of how plant and intercanopy patch dynamics, distributions, and connectivity influence catchment‐scale responses. To address this gap, we established research catchments in the Sonoran and Chihuahuan Deserts (near Green Valley, Arizona and near Las Cruces, New Mexico, respectively) that represent shrub encroachment in contrasting arid climates. Our main goals in the coordinated observations were to: (a) independently measure the components of the catchment water balance, (b) deploy sensors to quantify the spatial patterns of ecohydrological processes, (c) use novel methods for characterizing catchment properties, and (d) assess shrub encroachment impacts on ecohydrological processes through modelling studies. Datasets on meteorological variables; energy, radiation, and CO2 fluxes; evapotranspiration; soil moisture and temperature; and runoff at various scales now extend to nearly 10 years of observations at each site, including both wet and dry periods. Here, we provide a brief overview of data collection efforts and offer suggestions for how the coordinated datasets can be exploited for ecohydrological inferences and modelling studies. Given the representative nature of the catchments, the available databases can be used to generalize findings to other catchments in desert landscapes

Long‐term research catchments to investigate shrub encroachment in the Sonoran and Chihuahuan deserts: Santa Rita and Jornada experimental ranges

Woody plant encroachment is a global phenomenon whereby shrubs or trees replace grasses. The hydrological consequences of this ecological shift are of broad interest in ecohydrology, yet little is known of how plant and intercanopy patch dynamics, distributions, and connectivity influence catchment-scale responses. To address this gap, we established research catchments in the Sonoran and Chihuahuan Deserts (near Green Valley, Arizona and near Las Cruces, New Mexico, respectively) that represent shrub encroachment in contrasting arid climates. Our main goals in the coordinated observations were to: (a) independently measure the components of the catchment water balance, (b) deploy sensors to quantify the spatial patterns of ecohydrological processes, (c) use novel methods for characterizing catchment properties, and (d) assess shrub encroachment impacts on ecohydrological processes through modelling studies. Datasets on meteorological variables; energy, radiation, and CO2 fluxes; evapotranspiration; soil moisture and temperature; and runoff at various scales now extend to nearly 10 years of observations at each site, including both wet and dry periods. Here, we provide a brief overview of data collection efforts and offer suggestions for how the coordinated datasets can be exploited for ecohydrological inferences and modelling studies. Given the representative nature of the catchments, the available databases can be used to generalize findings to other catchments in desert landscapes. © 2021 John Wiley & Sons LtdNational Science Foundation12 month embargo; first published online 2 January 2021This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Long‐term research catchments to investigate shrub encroachment in the Sonoran and Chihuahuan deserts: Santa Rita and Jornada experimental ranges

Woody plant encroachment is a global phenomenon whereby shrubs or trees replace grasses. The hydrological consequences of this ecological shift are of broad interest in ecohydrology, yet little is known of how plant and intercanopy patch dynamics, distributions, and connectivity influence catchment-scale responses. To address this gap, we established research catchments in the Sonoran and Chihuahuan Deserts (near Green Valley, Arizona and near Las Cruces, New Mexico, respectively) that represent shrub encroachment in contrasting arid climates. Our main goals in the coordinated observations were to: (a) independently measure the components of the catchment water balance, (b) deploy sensors to quantify the spatial patterns of ecohydrological processes, (c) use novel methods for characterizing catchment properties, and (d) assess shrub encroachment impacts on ecohydrological processes through modelling studies. Datasets on meteorological variables; energy, radiation, and CO2 fluxes; evapotranspiration; soil moisture and temperature; and runoff at various scales now extend to nearly 10 years of observations at each site, including both wet and dry periods. Here, we provide a brief overview of data collection efforts and offer suggestions for how the coordinated datasets can be exploited for ecohydrological inferences and modelling studies. Given the representative nature of the catchments, the available databases can be used to generalize findings to other catchments in desert landscapes. © 2021 John Wiley & Sons LtdNational Science Foundation12 month embargo; first published online 2 January 2021This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Debris Field of the July 19, 2009, Impact in Jupiter and Its Long-term Evolution

A multi-platform suite of imaging and spectroscopic observations of Jupiter\u27s atmosphere tracked the evolution of the debris field of an unknown impactor on 2009 July 19. The initial debris field is similar to those of intermediate Shoemaker-Levy 9 fragments, suggesting a body hundreds of meters in size, if icy, entering from the west and slightly north. The field is detectable in the visible as dark material and in the near-IR by high-altitude particulate reflectivity; it was quickly redistributed by different zonal flows across its latitudinal range. At first, the particulate field was highly correlated with areas of enhanced temperatures and enhanced ammonia and ethane emission, but this was no longer true by mid-August. As of Sept. 2, the debris field was undetectable in the thermal, detectable in the visible with good seeing, and still prominent near 2 microns wavelength. Visibly, the impact scar consists of two dark regions along the same latitude, ostensibly different from the central bright region associated with the near-IR debris pattern. Both morphologies show eastern and western extensions propagating away from the original impact site, which appear to be influenced by flows around vortices previously undetected in Jupiter atmosphere. These observations define the flow field just north of Jupiter\u27s southern polar vortex at higher altitudes than tracked in Jupiter\u27s main cloud deck